Preheat oven to 450° F. Cut cauliflower into bite-sized florets. Toss in a bowl with oil, salt, pepper, and garlic powder. Put the flour in a plastic bag (a reused produce bag works well for this) with the cauliflower and shake until the cauliflower is well-coated with the flour.
Prepare a greased baking sheet or a baking sheet lined with parchment and place the flour-covered cauliflower on the sheet. Bake for 18 minutes.
In the same bowl you used to toss the cauliflower and oil, gently toss the cauliflower together with the hot sauce. When the cauliflower is nicely coated with the sauce, gently place the cauliflower bites back on the pan and pop them into the oven for another 5-8 minutes.
Serve with celery and your favorite ranch dressing.